Peer-reviewed veterinary case report
Rising antibiotic resistance and MRSP in UK dogs and cats
By Beever, L et al.·Published in The Veterinary record·2015·Department of Clinical Sciences and Services, United Kingdom·View original on PubMed →
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Original publication title: Increasing antimicrobial resistance in clinical isolates of Staphylococcus intermedius group bacteria and emergence of MRSP in the UK.
Plain-English summary
A study found that 0.7% of Staphylococcus intermedius group bacteria from dogs and cats in the UK were resistant to common antibiotics, with a notable emergence of meticillin-resistant Staphylococcus pseudintermedius (MRSP). This resistance was particularly concerning for antibiotics like amoxicillin and cefalexin, which showed increasing resistance over time. The findings highlight the importance of responsible antibiotic use in veterinary medicine to combat rising resistance. Pet owners should be aware of these trends, especially if their pets are being treated for infections.
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Abstract
Frequencies of antimicrobial resistance were determined amongst 14,555 clinical Staphylococcus intermedius group (SIG) isolates from UK dogs and cats to estimate resistance trends and quantify the occurrence of meticillin-resistant Staphylococcus pseudintermedius (MRSP). Reports from two diagnostic laboratories (13,313 general submissions, 1242 referral centre only submissions) were analysed retrospectively (2003/2006-2012). MRSP were defined by phenotypic resistance to meticillin and concurrent broad β-lactam resistance; a subset was confirmed genetically (SIG-specific nuc and mecA). Trends were analysed by Cochran-Armitage test. Resistance remained below 10 per cent for cefalexin, amoxicillin-clavulanic acid and the fluoroquinolones. Increasing resistance trends were seen in both laboratories for ampicillin/amoxicillin (both P<0.001), cefovecin (both P<0.046) and enrofloxacin (both P<0.02). Resistance to cefalexin increased over time in referral hospital isolates (P<0.001) to clindamycin (P=0.01) and trimethoprim-sulfamethoxazole (P=0.001) amongst general laboratory submissions. Overall, 106 MRSP were isolated (0.7 per cent of submissions) including 32 (2.6 per cent of submissions, all genetically confirmed) from the referral centre population (inter-laboratory difference P<0.001). Against a background of widely susceptible SIG isolates, a new trend of increasing resistance to important antimicrobials was identified overtime and the emergence of MRSP from UK clinical cases was confirmed. Attention to responsible use of antibacterial therapy in small animal practice is urgently needed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25376505/