Peer-reviewed veterinary case report
Improving skin and hair in dogs with health issues using autophagy
By Kim, Yoonji et al.·Published in Frontiers in veterinary science·2023·Department of Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Induction of autophagy improves skin and hair conditions in dogs with underlying diseases.
- Species:
- dog
Plain-English summary
A group of 22 dogs with poor skin and hair, suffering from conditions like canine atopic dermatitis (CAD) or pituitary-dependent hyperadrenocorticism (PDH), were treated with a special autophagy inducer (AI) to see if it could help their skin health. After 8 weeks of treatment, the dogs showed significant improvements in their skin condition and hair quality, with reduced inflammation and better skin barrier function. The AI helped decrease harmful substances in the skin that contribute to damage. Overall, the dogs appeared to be more comfortable and had healthier skin and fur after the treatment.
People also search for: dog skin problems treatment · atopic dermatitis in dogs · improving dog hair condition · pituitary-dependent hyperadrenocorticism treatment
Abstract
BACKGROUND: Autophagy was reported to play a crucial role in maintaining general and skin health. METHODS: The study used a synthesized autophagy inducer (AI) (Aquatide™ cospharm Inc.; Daejeon, Korea), for evaluating the effects of autophagy on skin and hair in dogs. Twenty-two dogs with poor skin and hair which were diagnosed with canine atopic dermatitis (CAD) or pituitary-dependent hyperadrenocorticism (PDH) were included. Clinical scores using Canine Atopic Dermatitis Extent and Severity Index-04 (CADESI-04), Pruritus Visual Analog Scale (PVAS) and skin barrier function using measurement of transepidermal water loss (TEWL) were evaluated and canine keratinocytes were also usedinvestigation of pro-inflammatory cytokines after AI treatment. RESULTS: In the AI group, clinical scores and skin barrier function were improved at week 8 significantly compared to in the other groups. In particular, the AI significantly improved the hair surface damage at 8 weeks compared to the baseline., the AI reduced pro-inflammatory cytokines by activating the 78-kDa glucose-regulated protein (GRP78). CONCLUSION: AI improve skin barrier function and hair damage and reduce pro-inflammatory cytokines by inhibiting reactive oxygen species (ROS) production in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36777662/