Induction of chronic asthma up regulated the transcription of senile factors in male rats.

Abstract

BACKGROUND: The main characteristic of asthma is chronic inflammation. We examined cellular senescence by histology and molecular assay in the lungs of a rat model of asthma. This model comprises sensitization by several intraperitoneal injections of ovalbumin with aluminium hydroxide, followed by aerosol challenges every other day. RESULTS: Data showed that asthma induction caused histological changes including, hyperemia, interstitial pneumonia, fibrinogen clots, and accumulation of inflammatory cells in the pleura. There is an elevation of IL-1&#x3b2; and NF-kB proteins in the asthmatic group (P&#x2009;<&#x2009;0.001) compared to the control group. The expression of &#xdf;-galactosidase increased (P&#x2009;<&#x2009;0.01), while the expression of Klotho and Sox2 genes was decreased in the lung tissue of the asthmatic group (P&#x2009;<&#x2009;0.01). CONCLUSION: Taken together, these findings suggest that asthmatic conditions accelerated the cellular senescence in the lung tissue.