Peer-reviewed veterinary case report
Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration.
- Journal:
- Journal of visualized experiments : JoVE
- Year:
- 2020
- Authors:
- Frank, Dmitry et al.
- Affiliation:
- Soroka University Medical Center and the Faculty of Health Sciences
- Species:
- rodent
Abstract
Traumatic brain injury (TBI) is a major cause of death and disability. Diffuse axonal injury (DAI) is the predominant mechanism of injury in a large percentage of TBI patients requiring hospitalization. DAI involves widespread axonal damage from shaking, rotation or blast injury, leading to rapid axonal stretch injury and secondary axonal changes that are associated with a long-lasting impact on functional recovery. Historically, experimental models of DAI without focal injury have been difficult to design. Here we validate a simple, reproducible and reliable rodent model of DAI that causes widespread white matter damage without skull fractures or contusions.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32449735/