Peer-reviewed veterinary case report
Induction of Sepsis Via Fibrin Clot Implantation.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2021
- Authors:
- Ghanta, Sailaja et al.
- Affiliation:
- Department of Pediatric Newborn Medicine · United States
Abstract
Implantation of bacteria embedded in a fibrin clot allows for successful establishment of sepsis in preclinical models. This model allows the investigator to modulate the strain of bacteria as well as the bacterial load delivered. As it allows for a slow release of standardized bacteria, the use of a fibrin clot model may be considered in studying the initial and later phases of sepsis and the host response to infection. Here we describe methods for performing the fibrin clot model of sepsis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34048004/