Peer-reviewed veterinary case report
Induction of Type 2 Diabetes in Mice to Understand Vascular Changes That Drive Diabetic Retinopathy.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2023
- Authors:
- Attrill, Emily et al.
- Affiliation:
- Tasmanian School of Medicine · Australia
- Species:
- rodent
Abstract
Diabetic retinopathy is a common complication of type 2 diabetes. Research into this comorbidity is challenging due to the slow progression of pathological changes and the limited transgenic models available to study disease progression and mechanistic changes. Here, we describe a non-transgenic mouse model of accelerated type 2 diabetes using a high-fat diet in combination with streptozotocin delivered via osmotic mini pump. This model, when subjected to fluorescent gelatin vascular casting, can be used to study vascular changes in type 2 diabetic retinopathy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37326701/