Peer-reviewed veterinary case report
How long do dogs treated with carboplatin excrete platinum in urine
By Janssens, T et al.·Published in Veterinary and comparative oncology·2015·Department of Pharmacy & Pharmacology, Netherlands·View original on PubMed →
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Original publication title: Inductively coupled plasma mass-spectrometric determination of platinum in excretion products of client-owned pet dogs.
- Species:
- dog
Plain-English summary
A group of dogs treated with carboplatin, a chemotherapy drug, showed increased levels of platinum in their urine, feces, and saliva for up to 21 days after treatment. The highest amounts of platinum were found in their urine during the first five days. This study highlights the importance of handling these dogs carefully after they receive chemotherapy, as their excretion products can pose risks to owners and veterinary staff. The findings may help improve safety guidelines for managing pets undergoing cancer treatment.
People also search for: dog chemotherapy side effects · carboplatin for dogs · handling dogs after cancer treatment
Abstract
Residues of antineoplastic drugs in canine excretion products may represent exposure risks to veterinary personnel, owners of pet dogs and other animal care-takers. The aim of this study was to measure the extent and duration of platinum (Pt) excretion in pet dogs treated with carboplatin. Samples were collected before and up to 21 days after administration of carboplatin. We used validated, ultra-sensitive, inductively coupled plasma-mass spectrometry assays to measure Pt in canine urine, faeces, saliva, sebum and cerumen. Results showed that urine is the major route of elimination of Pt in dogs. In addition, excretion occurs via faeces and saliva, with the highest amounts eliminated during the first 5 days. The amount of excreted Pt decreased over time but was still quantifiable at 21 days after administration of carboplatin. In conclusion, increased Pt levels were found in all measured excretion products up to 21 days after administration of carboplatin to pet dogs, with urine as the main route of excretion. These findings may be used to further adapt current veterinary guidelines on safe handling of antineoplastic drugs and treated animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23714139/