Peer-reviewed veterinary case report
Two dogs with Basidiobolus ranarum fungal infection causing skin
By Greene, Craig E et al.·Published in Journal of the American Veterinary Medical Association·2002·Department of Small Animal Medicine, United States·View original on PubMed →
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Original publication title: Infection with Basidiobolus ranarum in two dogs.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog developed a severe skin infection after spending a lot of time in water and soil, leading to swelling and lesions on its limbs. Another dog had repeated coughing and breathing problems due to a lung infection. Both dogs were treated with antibiotics and antifungal medications, but the first dog did not improve and had to be euthanized due to liver damage. The second dog managed to control its coughing with intermittent treatment over three years, despite also experiencing liver issues.
People also search for: dog skin infection treatment · dog coughing and breathing problems · Basidiobolus ranarum in dogs · liver damage from dog medication · dog fungal infection symptoms
Abstract
Basidiobolus ranarum is a saprophytic fungus in the environment that also is a part of the endogenous microflora in the gastrointestinal tract of several vertebrates. These organisms may penetrate skin or muscosa of humans and other animals, causing granulomatous inflammation. Two dogs infected with B. ranarum had prolonged or repeated exposure to water or soil in their environment. One dog had progressive subcutaneous infection of all the limbs, and the other dog had recurrent coughing and dyspnea caused by tracheobronchitis. In both dogs, secondary bacterial infection of the lesions was evident. Treatment of the dog with subcutaneous infection involved cutaneous dressings and sequential use of enrofloxacin and itraconazole; however, this resulted in suspected liver damage without clinical improvement. Subsequent treatment with potassium iodide and a lipid formulation of amphotericin B was also unsuccessful, and the dog was euthanatized. The other dog was treated alternately with enrofloxacin and itraconazole. When the clinical signs and infection returned, combination treatment with both drugs was more effective; however, the dog developed liver damage. Subsequent treatment with enrofloxacin on an intermittent basis controlled the dog's coughing during a 3-year period.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12184703/