Peer-reviewed veterinary case report
Infectivity of porcine circovirus 1 and circovirus 2 in primary porcine hepatocyte and kidney cell cultures.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2006
- Authors:
- Hirai, Takuya et al.
- Affiliation:
- Nippon Institute for Biological Science · Japan
Abstract
Infectivity of porcine circovirus (PCV) 1 and PCV2 was examined in primary porcine hepatocyte culture by comparing that of PCV in primary kidney cell culture. The virus titer of PCV2-infected hepatocyte cultures was higher than that of the PCV1-infected hepatocyte cultures and the PCV-infected kidney cell cultures. The number of virus-positive cells was most abundant in PCV2-infected hepatocyte cultures as determined by immunohistochemistry and/or in situ hybridization. The results of our data suggest that PCV2 preferably infects cultured hepatocytes as observed in the liver of pigs with postweaning multisystemic wasting syndrome.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16520543/