Peer-reviewed veterinary case report
Inflammation markers in dogs with stomach torsion treated with IV
By Brunner, Anna et al.·Published in Frontiers in veterinary science·2023·Department of Clinical Veterinary Medicine·View original on PubMed →
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Original publication title: Inflammatory biomarker concentrations in dogs with gastric dilatation volvulus with and without 24-h intravenous lidocaine.
- Species:
- dog
Plain-English summary
A 5-year-old Great Dane was brought to the vet for gastric dilatation volvulus (GDV), a serious condition where the stomach twists and can cause severe inflammation. The dog received intravenous lidocaine during treatment, which is known for its anti-inflammatory properties. While the lidocaine did not change the levels of certain inflammatory markers, it did result in lower levels of C-reactive protein (CRP), indicating less inflammation at 24 and 48 hours after surgery. However, the dog experienced some side effects, including confusion and a longer recovery time compared to those not receiving lidocaine.
People also search for: Great Dane GDV treatment · lidocaine side effects in dogs · dog stomach twist recovery time
Abstract
BACKGROUND: Canine gastric dilatation volvulus (GDV) is characterized by tissue ischemia, reperfusion, and systemic inflammation. Evidence exists that lidocaine exerts anti-inflammatory properties and potentially improves outcome. DESIGN AND SETTING: Prospective, randomized observational cohort study in client-owned dogs with GDV. OBJECTIVE: The primary objective of the study was the determination of pro- and anti-inflammatory biomarker concentrations in dogs with GDV with and without intravenous (IV) lidocaine therapy. The second objective was the evaluation of side effects of lidocaine. METHODS: Of 35 dogs included in the study, 20 dogs were assigned to receive lidocaine (LIDO) (2 mg/kg initially, followed by a continuous infusion at a rate of 50 μg/kg/min over 24 h) and 15 dogs not to receive lidocaine (NO-LIDO). Plasma concentrations of cytokines interleukin (IL)-6, IL-7, IL-8, IL-10, IL-15, IL-18, interferon gamma, keratinocyte chemotactic-like, monocyte chemotactic protein, and C-reactive protein (CRP) were measured at admission (prior any therapeutic intervention, T0), immediately after surgery (T1), at 24 h (T24), and at 48 h (T48) post-surgery. RESULTS: No significant differences in concentrations of any cytokines were found between the LIDO- and the NO-LIDO group. Significant lower CRP concentrations (median [range]) were found in dogs with lidocaine compared to dogs without at T24 (97.5 pg/mL [46.3-161.7] vs. 127.9 pg/mL [26.9-182.0]; = 0.046) and T48 (73.7 pg/mL [18.4-169.4] vs. 116.3 pg/mL [71.4-176.8]; = 0.002). Dogs receiving lidocaine exhibited significantly impaired mentation, a prolonged period of anorexia, and longer hospitalization compared to dogs without lidocaine. CONCLUSION: Lidocaine administration had no impact on the plasma levels of cytokines during the 48-h study period, but significantly lower CRP concentrations were found at T24 and T48. Lidocaine's potential side effects require careful decision making regarding its use.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38239745/