Peer-reviewed veterinary case report
C-reactive protein and cytokine levels in dogs with systemic
By Gommeren, Kris et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2018·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Inflammatory cytokine and C-reactive protein concentrations in dogs with systemic inflammatory response syndrome.
- Species:
- dog
Plain-English summary
A group of 69 dogs with systemic inflammatory response syndrome (SIRS) were evaluated for high levels of certain proteins in their blood that indicate inflammation. Many of these dogs showed elevated C-reactive protein (CRP) levels when they were first seen, and while these levels decreased during their hospital stay, they did not predict which dogs would survive or not. Most dogs that returned for follow-up visits had normal CRP levels after treatment. This study highlights that while CRP levels are important for monitoring inflammation, they don't determine the outcome for dogs with SIRS.
People also search for: dog inflammation symptoms · high CRP levels in dogs · SIRS treatment in dogs · dog emergency care · dog recovery from systemic inflammatory response syndrome
Abstract
OBJECTIVE: To evaluate C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) kinetics in dogs with a systemic inflammatory response syndrome (SIRS) presented to an emergency service. We hypothesized serum CRP concentrations would increase and vary during hospitalization, and would correlate with plasma IL-6 and TNF-α concentrations, vary in magnitude according to the underlying disease, and predict survival. DESIGN: Prospective, observational, clinical study. SETTING: University emergency department. ANIMALS: Sixty-nine dogs with SIRS weighing over 5 kg who could tolerate the blood sampling. INTERVENTIONS: Serum and plasma were collected (and stored at -80°C) at presentation (T0), after 6 (T6), 12 (T12), 24 (T24), and 72 (T72) hours, and at a follow-up visit at least 1 month after discharge (T1m). Underlying diseases were categorized as infection (I), neoplasia (N), trauma (T), gastric-dilation and volvulus (GDV), other gastrointestinal (GI), renal (R), and miscellaneous (M) disease. MEASUREMENTS AND MAIN RESULTS: Serum CRP concentration was measured using a canine-specific immunoturbidimetric assay. Biologically active plasma IL-6 and TNF-α concentrations were assessed using bioassays. Forty-four dogs survived, 8 died, and 17 were euthanized. Nineteen dogs had follow-up visits. At T0, serum CRP concentration was above the reference interval in 73.1% (49/67), and was within the reference interval (0-141.9 nmol/L) throughout hospitalization in only 6% (4/67). Serum CRP concentrations were significantly higher (P < 0.0001) at T0 (882.9 ± 1082.9 nmol/L) and at all time points during hospitalization (P < 0.0001) compared to T1m, with highest concentrations observed at T24 (906. 7 ± 859.0 nmol/L). At T1m, serum CRP concentrations were within the reference interval (22.9 ± 42.9 nmol/L) in 95% (18/19) of dogs. Logarithmic concentrations of serum CRP and plasma IL-6 were significantly correlated (P < 0.001, r = 0.479). None of the measured cytokines were associated with disease category or outcome. CONCLUSIONS: Serum CRP concentration is increased in dogs with SIRS, and decreases during treatment and hospitalization. Serum CRP, plasma IL-6, and plasma TNF-α concentrations cannot predict outcome in dogs with SIRS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29236338/