Peer-reviewed veterinary case report
How acetate and lactate fluids affect dog blood and electrolytes
By Klein-Richers, Ute et al.·Published in Frontiers in veterinary science·2022·Clinic of Small Animal Medicine, Germany·View original on PubMed →
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Original publication title: Influence of acetate- vs. lactate-containing fluid bolus therapy on acid-base status, electrolytes, and plasma lactate in dogs.
- Species:
- dog
Plain-English summary
A group of dogs showing signs of dehydration were treated with either an acetate-containing fluid or a lactate-containing fluid to see which worked better for restoring their health. Both treatments helped lower the dogs' heart rates and improved their overall condition, but the acetate solution was more effective at reducing plasma lactate levels and balancing certain electrolytes. After receiving the fluids, the dogs showed positive changes in their blood tests, indicating that both options can be beneficial for dogs needing fluid therapy.
People also search for: dog dehydration treatment · fluid therapy for dogs · acetate vs lactate fluids for dogs
Abstract
OBJECTIVE: Acetate- and lactate-containing fluids influence the acid-base and electrolyte status. This prospective, randomized, clinical study compared two balanced crystalloid solutions regarding their influence on acid-base status, electrolytes, and lactate values, when given to dogs as a resuscitation bolus of 30 mL/kg. MATERIAL AND METHODS: One hundred client-owned dogs presenting to the emergency service with signs of fluid deficits were randomly assigned to receive an intravenous bolus of 30 mL/kg of either a lactate- (LAC), or an acetate-containing solution (ACET). Before and after the bolus, vital parameters were assessed, and a venous blood gas analysis was performed. RESULTS: Both solutions performed equally well in decreasing the heart rate (ACET: -10 ± 27 bpm, LAC: -12 ± 30 bpm;= 0.737). The acetate-containing solution caused a significant decrease in plasma lactate levels (= 0.016), anion gap (< 0.001), and potassium (< 0.001), and a significant increase in chloride (< 0.001), and ionized calcium (= 0.014). The lactate-containing solution caused a significant decrease in anion gap (< 0.001), sodium (= 0.016), and potassium (= 0.001), and a significant increase in chloride (< 0.001). ACET causes a stronger decrease in plasma lactate (= 0.015), sodium (= 0.039), potassium (= 0.006), and an increase in chloride (< 0.001), and ionized calcium (= 0.016) compared to LAC. CONCLUSION: Both solutions caused mild changes in electrolyte concentrations and had minor influence on acid-base status when used for bolus therapy in dogs with fluid deficits. Further studies are needed to evaluate their influence on acid-base status, lactate, and electrolytes when used in larger volumes and for a longer time span.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35968021/