Peer-reviewed veterinary case report
Influence of donor microbiota on the severity of experimental graft-versus-host-disease.
- Journal:
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- Year:
- 2013
- Authors:
- Tawara, Isao et al.
- Affiliation:
- Department of Internal Medicine · United States
Abstract
The link between microbial flora and the shaping of immune responses is being increasingly appreciated, and recent data have uncovered a role for recipient microbiota in the severity of graft-versus-host disease (GVHD). The impact of donor microbiota on T cell-mediated alloresponses and GVHD is not known, however. Using multiple clinically relevant murine models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T cells from specific pathogen-free and germ-free donors, and found that donor microbiota does not alter the expansion or differentiation of alloreactive T cells or the severity of GVHD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22982686/