Peer-reviewed veterinary case report
Hydrochlorothiazide lowers calcium oxalate risk in female cats
By Hezel, Alisha et al.Ā·Published in Veterinary therapeutics : research in applied veterinary medicineĀ·2007Ā·Department of Small Animal Clinical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Influence of hydrochlorothiazide on urinary calcium oxalate relative supersaturation in healthy young adult female domestic shorthaired cats.
- Species:
- cat
Plain-English summary
A group of healthy young female domestic shorthaired cats was given a medication called hydrochlorothiazide to see if it could help reduce the risk of calcium oxalate crystals in their urine. After two weeks, the cats showed lower levels of calcium oxalate saturation in their urine when taking the medication compared to when they received a placebo. This suggests that hydrochlorothiazide might be helpful for managing cats prone to forming calcium oxalate stones, but more research is needed before it can be recommended for those specific cases.
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Abstract
Hydrochlorothiazide (1 mg/kg PO q12h) or placebo was administered to healthy cats for 2 weeks in a masked, placebo-controlled, crossover-design study, and 24-hour urine samples were collected. When cats received hydrochlorothiazide, 24-hour urine volume, ammonia, chloride, creatinine, magnesium, oxalic acid, phosphate, potassium, and sodium were significantly higher than when cats received placebo. Hydrochlorothiazide was associated with significantly lower urinary saturation for calcium oxalate, but no difference was found in 24-hour urine calcium and citrate, urinary saturation for struvite, or blood ionized calcium. Hydrochlorothiazide decreased urinary saturation for calcium oxalate and could be useful in managing cats with calcium oxalate uroliths. Results of this study, however, should not be extrapolated to cats that form calcium oxalate uroliths.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18183543/