Peer-reviewed veterinary case report
Influence of Th2 cells on hair cycle/growth after repeated cutaneous application of hapten.
- Journal:
- Clinical and experimental dermatology
- Year:
- 2014
- Authors:
- Sugita, K et al.
- Affiliation:
- Department of Dermatology · Japan
- Species:
- rodent
Abstract
Exposure to contact allergens in order to produce allergic contact dermatitis (ACD) seems to induce hair cycle/growth, but the mechanism of this remains unclear. In the current study, we investigated this mechanism and found that repeated application of hapten induced production of interleukin (IL)-4 in lymph-node immune cells. In addition, hair growth was induced in mice after the adoptive transfer of T-helper (Th)2 cells that had been purified from mice exposed to repeated cutaneous application of hapten. These findings lead us to speculate that Th2 cells that are repeatedly hapten-sensitized are recruited to hapten-challenged skin areas, and thus stimulate the production of IL-4 in the vicinity of the hair follicles, which influences hair cycle/growth. Our results may provide fundamental insights into the mechanism of contact hypersensitivity-induced hair cycle/growth.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24266764/