Peer-reviewed veterinary case report
Treatment effects on dogs with partly removed grade-2 mast cell tumors
By Vincenti, S & Findji, F·Published in Schweizer Archiv fur Tierheilkunde·2017·VRCC Veterinary Referrals, United Kingdom·View original on PubMed →
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Original publication title: Influence of treatment on the outcome of dogs with incompletely excised grade-2 mast cell tumors.
- Species:
- dog
Plain-English summary
A group of dogs with incompletely removed grade-2 mast cell tumors (a type of skin cancer) was studied to see if additional treatments like surgery, radiation, or chemotherapy would improve their outcomes. Out of 113 dogs, 92 received some form of treatment while 23 were just monitored. After follow-up, many dogs showed no signs of remaining cancer, and the overall survival rates were high at 92% after one year and 82% after two years. The results suggest that immediate additional treatments may not be necessary, and careful monitoring could be a suitable option for these dogs.
People also search for: dog mast cell tumor treatment · grade-2 mast cell tumor prognosis · dog skin cancer monitoring
Abstract
In this study we compared the outcomes of dogs with incompletely-excised grade-2 mast cell tumors (incompletely- excised grade-2 MCTs) either adjuvantly treated or not. Dogs with a grade-2 mast cell tumour (MCT) excised either incompletely or with narrow (<5mm) margins, without local recurrence or metastasis at the time of presentation and with a minimum follow-up of 10 months were included in the study. Dogs were separated in 2 groups: treatment (surgery, radiation therapy, chemotherapy or combination of those) and no-treatment. The original excision was incomplete in 90 dogs and narrow in 25 dogs. Ninety-two cases (80%) were treated and 23 (20%) were not treated, but only monitored. Pathology after revision excision found no signs of residual disease in 47/56 cases (84%). Local recurrence was confirmed in 7 dogs, suspected but not confirmed in 2 dogs. Metastatic disease was confirmed in 13 dogs and suspected but not confirmed in 11 dogs. Forty-six dogs died and 69 were still alive at the time of data collection. The 1-yr and 2-yr survival rates were 92% and 82%, respectively. No statistical differences were found regarding disease-free intervals, survival times, recurrence rates, metastatic rates, 1-year and 2-year survival rates between groups, or depending on treatment modality within the treatment group. Based on the finding that the outcome of incompletely-excised grade-2 MCTs was unaffected by adjuvant treatments, this study suggests that immediate systematic adjuvant treatment of incompletely-excised grade-2 MCTs may not be recommended over attentive monitoring and action upon uncommon recurrence.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28248186/