Peer-reviewed veterinary case report
How vitamin E affects mast cell allergy chemicals in dogs
By Gueck, Thomas et al.·Published in Veterinary dermatology·2002·Institute of Physiological Chemistry, Germany·View original on PubMed →
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Original publication title: Influence of vitamin E on mast cell mediator release.
- Species:
- dog
Plain-English summary
A study looked at how vitamin E affects mast cells, which are involved in allergic reactions, in dogs with skin allergies (atopic dermatitis). When these mast cells were treated with vitamin E, they released less histamine and another inflammatory substance called prostaglandin D2, especially when stimulated. This suggests that vitamin E could help reduce inflammation in dogs with skin problems. While the treatment showed promise, it’s important to consult your veterinarian before starting any new supplements for your pet.
People also search for: dog skin allergies treatment · vitamin E for dogs · how to reduce dog itching
Abstract
We investigated the influence of vitamin E on mediator activity and release in a canine mastocytoma cell line (C2) as a model for canine atopic dermatitis. Cells were incubated without and with vitamin E (100 microm) for 24 h. The histamine and prostaglandin D2 (PGD2) release as well as the chymase and tryptase activity were measured. To stimulate the PGD2 and histamine release, cells were incubated with the wasp venom peptide mastoparan (50 microm) for 30 or 45 min. Nonstimulated as well as mastoparan-stimulated histamine and PGD2 release was reduced significantly in vitamin E-treated cells. The activity of chymase tended to decrease, but the tryptase activity of C2 cells was not influenced by vitamin E. These results indicate that vitamin E decreased the production and release of inflammatory mediators in C2 cells, suggesting that vitamin E might have a possible beneficial effect in inflammatory diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12464062/