Peer-reviewed veterinary case report
Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis.
- Journal:
- Journal of neuroimmunology
- Year:
- 2008
- Authors:
- Liu, Yutong et al.
- Affiliation:
- University of Nebraska Medical Center · United States
- Species:
- rodent
Abstract
Blood-borne macrophage ingress into brain in HIV-1 associated neurocognitive disorders governs the tempo of disease. We used superparamagnetic iron-oxide particles loaded into murine bone marrow-derived macrophages (BMM) injected intravenously into HIV-1 encephalitis mice to quantitatively assess BMM entry into diseased brain regions. Magnetic resonance imaging tests were validated by histological coregistration and enhanced image processing. The demonstration of robust BMM migration into areas of focal encephalitis provide 'proof of concept' for the use of MRI to monitor macrophage ingress into brain.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18653244/