Peer-reviewed veterinary case report
Ectopic ureters inherited in Entlebucher Mountain Dogs
By Fritsche, R et al.·Published in Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie·2014·Clinic for Animal Reproduction Medicine·View original on PubMed →
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Original publication title: Inheritance of ectopic ureters in Entlebucher Mountain Dogs.
- Species:
- dog
Plain-English summary
A study found that ectopic ureters (a condition where the ureters do not connect normally to the bladder) are common in Entlebucher Mountain Dogs, affecting nearly 20% of those examined. The research showed that male dogs were more likely to have this issue than females, suggesting a hereditary link. The condition can lead to various urinary problems, and affected dogs may need specialized treatment based on the severity of their symptoms. Understanding this genetic predisposition can help owners and vets manage the health of these dogs more effectively.
People also search for: Entlebucher Mountain Dog ectopic ureters · male dog urinary problems · hereditary conditions in Entlebucher Mountain Dogs
Abstract
To test the hypothesis of a heritable base of ectopic ureters (EU) in Entlebucher Mountain Dogs (EMD) and to elucidate associated risk factors and mode of inheritance of the disease, 565 EMD were clinically investigated and population genetic analyses performed. Based on the location of the most caudal termination of the ureteral openings, 552 EMD were classified into three phenotype groups trigone, intravesically and extravesically ectopic based on results of abdominal sonography, urethra-cystoscopy and/or contrast-enhanced computed tomography. One-third (32.9%) of the phenotyped animals had normal terminations of both ureters in the bladder trigone, 47.3% had at least one intravesicular ectopic termination and 19.8% had at least one extravesicular ectopic termination. Multivariate mixed logistic regression revealed gender as a risk factor associated with EU as males were more often affected than females. Complex segregation analysis indicated a hereditary basis for EU in EMD and the involvement of a major gene in the occurrence of the extravesicular EU phenotype.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24628724/