Peer-reviewed veterinary case report
Cranial cruciate ligament rupture inherited in Newfoundlands
By Wilke, Vicki L et al.·Published in Journal of the American Veterinary Medical Association·2006·Department of Animal Sciences, United States·View original on PubMed →
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Original publication title: Inheritance of rupture of the cranial cruciate ligament in Newfoundlands.
- Species:
- dog
Plain-English summary
A study found that about 22% of Newfoundlands may suffer from ruptured cranial cruciate ligaments (RCCL), which can cause limping and pain in their back legs. Researchers looked at the genetics of these dogs and discovered that RCCL might be inherited in a recessive manner, meaning that both parents could carry the gene without showing symptoms themselves. This information could help breeders identify and reduce the number of affected dogs in the future. If you have a Newfoundland, it's a good idea to discuss this with your vet, especially if you notice any signs of limping or discomfort.
People also search for: Newfoundland limping · cranial cruciate ligament injury in dogs · dog knee pain genetics
Abstract
OBJECTIVE: To determine prevalence, level of inbreeding, heritability, and mode of inheritance for rupture of the cranial cruciate ligament (RCCL) in Newfoundlands. DESIGN: Retrospective and recruitment study. ANIMALS: 574 client-owned Newfoundlands. PROCEDURE: Medical records from January 1, 1996, to December 31, 2002, were evaluated for prevalence of RCCL. A pedigree was constructed by use of recruited Newfoundlands with RCCL status based on results of veterinary examination; level of inbreeding, heritability, and mode of inheritance were calculated. RESULTS: Hospital prevalence for RCCL was 22%; dogs in the pedigree from the recruitment study had a mean level of inbreeding of 1.19 x 10(4), heritability of 0.27, and a possible recessive mode of inheritance with 51% penetrance for RCCL. CONCLUSIONS AND CLINICAL RELEVANCE: Identification of a genetic basis for RCCL in Newfoundlands provided evidence that investigators can now focus on developing methods to identify carriers to reduce the prevalence of RCCL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16426167/