Peer-reviewed veterinary case report
Duloxetine with foot stimulation helps calm bladder overactivity
By Schwen, Zeyad et al.·Published in American journal of physiology. Renal physiology·2013·Dept. of Urology·View original on PubMed →
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Original publication title: Inhibition of bladder overactivity by duloxetine in combination with foot stimulation or WAY-100635 treatment in cats.
- Species:
- cat
Plain-English summary
A group of cats with bladder overactivity were treated with duloxetine, a medication that helps manage this condition, along with foot stimulation to see if it would improve their symptoms. The cats showed significant improvement in bladder capacity with duloxetine alone, especially at a higher dose, and foot stimulation also helped. However, when duloxetine was combined with another drug called WAY-100635, the cats experienced even greater relief, with bladder capacity exceeding normal levels. This suggests that using duloxetine with WAY-100635 could be a promising new approach for treating overactive bladders in cats.
People also search for: cat bladder problems treatment · duloxetine for cat bladder overactivity · cat urinary incontinence medication
Abstract
The purpose of this study was to determine whether duloxetine [a serotonin (5-HT)-norepinephrine reuptake inhibitor] combined with transcutaneous foot stimulation or WAY-100635 (a 5-HT1A antagonist) can enhance inhibition of bladder overactivity in cats. Cystometrograms were performed on eight cats under α-chloralose anesthesia by infusing saline and then 0.25% acetic acid (AA) to induce bladder overactivity. To inhibit bladder overactivity, foot stimulation (5 Hz) was applied via transcutaneous pad electrodes to the right hindfoot at two and four times the threshold intensity for inducing a toe twitch. Duloxetine (0.003-3 mg/kg) was administered intravenously to determine the effect of combination treatment. After the 3 mg/kg dose of duloxetine, WAY-100635 (0.5 mg/kg) was given intravenously. AA irritation significantly (P < 0.0001) reduced bladder capacity to 42.7 ± 7.4% of the saline control capacity. Foot stimulation alone at both two and four times the threshold intensity significantly (P < 0.0001) inhibited bladder overactivity and increased bladder capacity to 66.7 ± 6.3% and 85.7 ± 6.5% of the saline control, respectively. Duloxetine alone dose dependently inhibited bladder overactivity and completely restored bladder capacity to the saline control (109 ± 15.5%) at 3 mg/kg. Although duloxetine combined with foot stimulation did not further enhance inhibition, WAY-100635 (0.5 mg/kg) given after 3 mg/kg duloxetine further increased (P = 0.008) bladder capacity to 162.2 ± 22.5% of the saline control. Although duloxetine and foot stimulation independently inhibited bladder overactivity, combined treatment did not enhance inhibition. Duloxetine combined with WAY-100635, however, synergistically enhanced bladder inhibition, indicating a potential novel treatment for overactive bladder if duloxetine is combined with a 5-HT1A receptor antagonist drug.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24154699/