Peer-reviewed veterinary case report
Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor.
- Journal:
- Nanoscale
- Year:
- 2018
- Authors:
- Huang, Qiaoxian et al.
- Affiliation:
- Institute of Chinese Medical Sciences · China
Abstract
A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29717743/