Peer-reviewed veterinary case report
Topical adelmidrol reduces allergic skin swelling in dogs
By Cerrato, Santiago et al.·Published in BMC veterinary research·2012·Departament de Farmacologí, Spain·View original on PubMed →
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Original publication title: Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis.
- Species:
- dog
Plain-English summary
A group of six Beagle dogs with allergic dermatitis showed skin swelling and irritation after being exposed to an allergen. They were treated with a topical cream containing adelmidrol for eight days, while the other side received a placebo. The dogs experienced a significant reduction in swelling and inflammation, and fewer mast cells (which contribute to allergic reactions) were found in skin samples after treatment. This suggests that adelmidrol could be an effective new option for managing allergic skin reactions in dogs.
People also search for: dog allergic dermatitis treatment · Beagle skin allergy cream · adelmidrol for dogs skin problems
Abstract
BACKGROUND: Adelmidrol is a semisynthetic derivative of azelaic acid and analogue of the anti-inflammatory compound palmitoylethanolamide (PEA). Based upon its physicochemical properties, adelmidrol is suitable for topical application. The main objective of the present study was to evaluate the efficacy of a topical adelmidrol emulsion on early and late inflammatory responses in hypersensitive dogs. Repeated intradermal injections of Ascaris suum extract were performed in both lateral thoracic areas of six conscious hypersensitive Beagle dogs, topically treated during 8 consecutive days. Adelmidrol (2%) was applied to one side and vehicle to the other. 24 hours after the last antigen challenge, two biopsies (adelmidrol- and vehicle-treated side) were obtained for each dog at the antigen injection site. RESULTS: A significant reduction in the antigen-induced wheal areas was observed on the 4th and 7th day of adelmidrol treatment. Moreover, cutaneous mast cell numbers were significantly decreased in biopsies obtained after 8 consecutive days of topical adelmidrol treatment. CONCLUSIONS: The results obtained in the present study show that topical treatment with adelmidrol might represent a new therapeutic tool in controlling the early and late allergic inflammatory skin responses in companion animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23181761/