Peer-reviewed veterinary case report
Inhibitory Effect ofCMU-Pb-L5 In a Subcutaneous Transplanted Tumor Model of Colorectal Cancer.
- Journal:
- International journal of medical sciences
- Year:
- 2024
- Authors:
- Chang, Xiaodan et al.
- Affiliation:
- Department of Neonatology · China
- Species:
- rodent
Abstract
() is a prevalent probiotic strain within thegenus, which has robust intestinal colonization capabilities. Previous studies have demonstrated the anticancer properties ofbothand. However, the mechanisms underlying its anticancer activityremain unclear. This study established a subcutaneous transplanted tumor model of colorectal cancer (CRC) in mice to investigate the impact ofCMU-Pb-L5. Various parameters including tumor volume, tumor weight, histological alterations in tumor tissue, levels of polyamines and immune-related cytokines in serum, as well as the expression of polyamine metabolism-related and apoptosis-related proteins were evaluated. The results suggested thatCMU-Pb-L5 exhibited inhibitory effects on tumor cell proliferation, promotion of tumor cell apoptosis, reduction in polyamine levels, and enhancement of the immune response in CRC mice. To sum up, these results suggested thatCMU-Pb-L5 holds promise for potential clinical applications in the treatment of CRC.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39439459/