Peer-reviewed veterinary case report
Insight into the early pathogenesis and therapeutic strategies of spinocerebellar ataxia type 3/machado-joseph disease from mouse models.
- Journal:
- Parkinsonism & related disorders
- Year:
- 2024
- Authors:
- Wang, Ying et al.
- Affiliation:
- School of Medical and Life Sciences · China
Abstract
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is the most common subtype of hereditary ataxia (HA), which is characterized by motor deficits and a lack of effective treatments, and imposes a huge physical, mental, and financial burden on patients and their families. Therefore, it is important to study the early pathogenesis of spinal cerebellar ataxia type 3 based on a mouse model for subsequent preventive treatment and seeking new therapeutic targets.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38749872/