Peer-reviewed veterinary case report
Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
- Journal:
- Metallomics : integrated biometal science
- Year:
- 2011
- Authors:
- Martinez-Finley, Ebany J et al.
- Affiliation:
- Vanderbilt University Medical Center · United States
Abstract
Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21210060/