Peer-reviewed veterinary case report
How gut health affects chronic kidney disease in cats and dogs
By Summers, Stacie & Quimby, Jessica·Published in Veterinary journal (London, England : 1997)·2024·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Insights into the gut-kidney axis and implications for chronic kidney disease management in cats and dogs.
- Species:
- cat
Plain-English summary
Chronic kidney disease (CKD) in cats and dogs can be tough to manage, but new research shows that the gut health of these pets plays a big role in their kidney function. When the balance of bacteria in the gut is off, it can lead to the buildup of harmful substances that worsen kidney problems. To help manage CKD, veterinarians are looking at ways to improve gut health through diet changes, probiotics, and other treatments. These approaches aim to restore balance in the gut, which may help protect the kidneys and improve overall health.
People also search for: cat kidney disease treatment · dog chronic kidney disease diet · probiotics for dogs with kidney problems
Abstract
Chronic kidney disease (CKD) in cats and dogs presents significant clinical challenges, with emerging research highlighting the pivotal role of the gut-kidney axis in its pathogenesis and management. Gut dysbiosis, characterized by alterations in the gut microbiome composition and function, contributes to microbial dysmetabolism of key nutrients causing uremic toxin accumulation and disruptions in amino acid, bile acid and fatty acid profiles. These disturbances in turn exacerbate renal dysfunction and systemic inflammation. Recent research in veterinary medicine, particularly in cats, supports the gut microbiome and microbial-derived metabolites as novel therapeutic targets. Potential therapeutic strategies targeting the gut microbiome and microbial dysmetabolism, including dietary management, probiotics, adsorbents, and addressing constipation, offer promising avenues for intervention to restore metabolic balance and preserve renal function. This review highlights the microbial influence on renal health and focuses on potential therapeutic strategies available to veterinarians to optimize the management of CKD in cats and dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38897377/