Peer-reviewed veterinary case report
How long insulin glargine works in healthy cats after one or two
By Marshall, Rhett D et al.·Published in Journal of feline medicine and surgery·2008·School of Veterinary Science, Australia·View original on PubMed →
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Original publication title: Insulin glargine has a long duration of effect following administration either once daily or twice daily in divided doses in healthy cats.
- Species:
- cat
Plain-English summary
A group of six healthy cats received insulin glargine either once a day or twice a day to see how well it controlled their blood sugar levels. The results showed that both dosing methods were effective, but the twice-daily dosing took longer to reach its lowest blood sugar level. Interestingly, some cats still had elevated blood sugar levels even after 24 hours, regardless of how often they received the insulin. This suggests that insulin glargine has a long-lasting effect, but more research is needed to find the best dosing schedule for diabetic cats.
People also search for: cat diabetes treatment · insulin glargine for cats · how often to give insulin to cats
Abstract
The pharmacological effects of glargine administered once or twice daily were compared in six healthy cats. A two-way crossover study was performed with insulin and glucose concentrations measured following subcutaneous administration of glargine once daily (0.5 U/kg) or twice daily (0.25 U/kg, repeated after 12h). Nadir glucose concentration and mean daily glucose concentration did not differ significantly following insulin administration once daily or twice daily in divided doses. Time to reach last glucose nadir differed, with longer intervals occurring following twice daily dosing. Blood glucose failed to return to baseline concentration by 24h in three of six cats in each treatment group. Insulin variables were not significantly different following once or twice daily dosing. This study in healthy cats demonstrates that glargine has a long duration of action with carry-over effects to the next day likely, regardless of dosing regimen. A study in diabetic cats is required to determine the best dosing regimen.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18703367/