Peer-reviewed veterinary case report
How clarithromycin affects cyclosporine dosing in cats
By Katayama, Masaaki et al.Ā·Published in Journal of feline medicine and surgeryĀ·2012Ā·Department of Veterinary Medicine, JapanĀ·View original on PubMed ā
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Original publication title: Interaction of clarithromycin with cyclosporine in cats: pharmacokinetic study and case report.
- Species:
- cat
Plain-English summary
A cat that had undergone a kidney transplant was given clarithromycin (CLM) along with cyclosporine (CsA) to see how it affected the medication levels in her body. The combination of these two medications significantly increased the effectiveness of CsA, allowing the vet to reduce the dosage needed by about 65% and change the administration from twice a day to just once daily. This approach not only helped manage the cat's condition better but also offered a more cost-effective and convenient treatment option for her owner.
People also search for: cat kidney transplant medication Ā· clarithromycin cyclosporine interaction Ā· cat immunosuppression treatment
Abstract
Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) trough levels in human transplant patients. However, the interaction of CLM with CsA has not been reported in cats. In this study, the effects of oral dosing of CLM on the pharmacokinetics and dosing of CsA in cats were investigated. Co-administration of CLM with CsA resulted in significant increases of oral bioavailability of CsA. In addition, CLM reduced the CsA dosage required to maintain the therapeutic CsA trough levels to almost 35% of the initial CsA therapy and the dose frequency was successfully replaced from a twice a day schedule to once a day in a feline kidney transplant patient. The addition of CLM to the regular CsA-based immunosuppression could be used as an effective alternative to classical ketoconazole treatment in feline kidney transplant patients and may result in substantial cost saving and convenience for the cat owners.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22412163/