Peer-reviewed veterinary case report
Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents.
- Journal:
- Journal of pharmacological sciences
- Year:
- 2014
- Authors:
- Akagi, Takanori et al.
- Affiliation:
- Department of Molecular and System Pharmacology · Japan
- Species:
- rodent
Abstract
We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25273233/