Peer-reviewed veterinary case report
Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.
- Journal:
- Nature neuroscience
- Year:
- 2011
- Authors:
- Chakrabarty, Paramita et al.
- Affiliation:
- Department of Neuroscience · United States
Abstract
We found that CNS-directed expression of interferon-γ (IFN-γ) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21572432/