Peer-reviewed veterinary case report
Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection.
- Journal:
- Infection and immunity
- Year:
- 2005
- Authors:
- Kelly, Michelle N et al.
- Affiliation:
- Department of Microbiology · United States
- Species:
- rodent
Abstract
We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R(-/-) mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15618203/