Peer-reviewed veterinary case report
Longer survival in dogs with mast cell tumors having exon 8 mutation
By Brocks, Bouvien A W et al.·Published in Veterinary pathology·2021·BB Surgery & Orthopedics, Netherlands·View original on PubMed →
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Original publication title: Internal Tandem Duplication of Exon 8 ofIs Associated With Longer Total Survival in Canine Cutaneous Mast Cell Tumors.
- Species:
- dog
Plain-English summary
A study found that dogs with skin tumors called cutaneous mast cell tumors (ccMCTs) that had a specific mutation in exon 8 lived longer than those with a different mutation in exon 11. Out of 221 dogs with ccMCTs, 33% had the exon 8 mutation, and none of these dogs died from the tumor, while 23% of those with the exon 11 mutation did. This suggests that testing for the exon 8 mutation could help identify less aggressive tumors, allowing for better treatment decisions. Overall, dogs with the exon 8 mutation had a better prognosis compared to those with the exon 11 mutation.
People also search for: dog skin tumor prognosis · canine mast cell tumor treatment · cutaneous mast cell tumor survival rate
Abstract
Canine cutaneous mast cell tumors (ccMCTs) have a highly variable biological behavior and accurate prognostication is essential for therapeutic intervention. Internal tandem duplications (ITD) of exon 11 are the most commonly detectedmutation in ccMCTs and are associated with poor prognosis and increased cellular proliferation. The prognostic value of detecting mutations in other exons ofhas not been systematically examined. In this study, we analyzed the prognostic value of ITD mutations of exon 8 inof ccMCTs in comparison to ccMCTs with ITD mutations of exon 11 and ccMCTs without mutations of exon 8 or 11. The mutational status, histological grade, KIT expression pattern, Ki67 index, AgNOR (argyrophilic nucleolar organizing region) score, and Ag67 score were determined in 221 ccMCTs, and outcome was available for 101 dogs. ITD mutations of exon 8 were found in 73/221 (33%), of exon 11 in 100/221 (45%), and none of these mutations in 50/221 (22%) of ccMCTs. None of the dogs with mutations of exon 8 died due to suspected ccMCT-related cause, but 23% dogs with ccMCTs with mutations of exon 11 died due to suspected ccMCT-related cause. Prognostic parameters in ccMCTs with exon 11 mutations were commonly associated with a high proliferative activity and poor prognosis, while prognostic markers in ccMCTs with mutations of exon 8 had lower values similar to those observed in ccMCTs without mutations in exons 8 or 11 of. This study indicates that screening for ITD mutations in exon 8 in ccMCTs may be helpful to identify less aggressive ccMCTs and may be recommended as a supplementary prognostic test.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33231140/