Peer-reviewed veterinary case report
International veterinary epilepsy task force consensus proposal: outcome of therapeutic interventions in canine and feline epilepsy.
- Journal:
- BMC veterinary research
- Year:
- 2015
- Authors:
- Potschka, Heidrun et al.
- Affiliation:
- Department of Pharmacology · Germany
Plain-English summary
Veterinary experts are calling for clearer guidelines to help diagnose and treat dogs with epilepsy, especially when their seizures don't respond to medication. They propose definitions for what it means when a dog is resistant to treatment and what partial success looks like. The recommendations also include various factors to consider when evaluating how well a treatment is working beyond just the number of seizures. By agreeing on these common standards, veterinarians can better manage individual cases and design more effective clinical studies. Overall, this effort aims to improve the way we understand and treat epilepsy in dogs.
Abstract
Common criteria for the diagnosis of drug resistance and the assessment of outcome are needed urgently as a prerequisite for standardized evaluation and reporting of individual therapeutic responses in canine epilepsy. Thus, we provide a proposal for the definition of drug resistance and partial therapeutic success in canine patients with epilepsy. This consensus statement also suggests a list of factors and aspects of outcome, which should be considered in addition to the impact on seizures. Moreover, these expert recommendations discuss criteria which determine the validity and informative value of a therapeutic trial in an individual patient and also suggest the application of individual outcome criteria. Agreement on common guidelines does not only render a basis for future optimization of individual patient management, but is also a presupposition for the design and implementation of clinical studies with highly standardized inclusion and exclusion criteria. Respective standardization will improve the comparability of findings from different studies and renders an improved basis for multicenter studies. Therefore, this proposal provides an in-depth discussion of the implications of outcome criteria for clinical studies. In particular ethical aspects and the different options for study design and application of individual patient-centered outcome criteria are considered.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26314300/