Peer-reviewed veterinary case report
International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs
- Journal:
- BMC Veterinary Research
- Year:
- 2015
- Authors:
- V. Hülsmeyer et al.
- Species:
- dog
Plain-English summary
Canine idiopathic epilepsy is a common brain condition that affects both purebred and mixed-breed dogs. Research has shown that different dog breeds can have unique signs, ways the condition is passed down, and how often they get it. Understanding these breed-specific differences is important for effectively managing epilepsy in dogs and can help guide future research. This study reviews what we know about breeds that are more likely to have idiopathic epilepsy due to genetic factors, including details like when seizures start, the types of seizures, and how well they respond to treatment. Overall, the findings emphasize the need for tailored approaches to treating epilepsy in different breeds.
Abstract
Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in particular our knowledge of those breeds studied. However, these studies also frequently revealed differences between the investigated breeds with respect to clinical features, inheritance and prevalence rates. Awareness and observation of breed-specific differences is important for successful management of the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted.
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Search related cases →Original publication: https://www.semanticscholar.org/paper/26316206