Peer-reviewed veterinary case report
Interplay of autophagy and apoptosis during PRRSV infection of Marc145 cell.
- Journal:
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Year:
- 2016
- Authors:
- Li, Shuaifeng et al.
- Affiliation:
- Huazhong Agricultural University · China
Abstract
Autophagy and apoptosis play essential roles 'in virus infection. Our study was performed to investigate the interplay between autophagy and apoptosis in PRRSV replication. In our present study, autophagy and apoptosis were induced by PRRSV infection. Viral replication was dampened/attenuated by autophagy deficient and potentiated by apoptosis inhibition. Furthermore, PRRSV replication was restored by apoptosis inhibition in autophagy deficient cells. Taken together, our findings unveil the functional relationship between autophagy and apoptosis during PRRSV replication.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26774368/