Peer-reviewed veterinary case report
Gelatinase enzyme levels in dog tumors and blood predict cancer
By Miya, Kanako et al.·Published in The Journal of veterinary medical science·2005·Department of Veterinary Science, Japan·View original on PubMed →
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Original publication title: Interpreting gelatinase activity in tumor tissue and serum as a prognostic marker of naturally developing canine tumors.
- Species:
- dog
Plain-English summary
A study looked at how gelatinase levels in tumor tissue and blood could help predict the behavior of tumors in dogs. Researchers collected samples from 60 dogs with tumors and found that higher gelatinase activity in both tissue and serum was linked to more aggressive tumors, especially those that were malignant. While benign tumors showed lower levels, malignant tumors had significantly higher gelatinase activity, suggesting that this could be a useful marker for assessing the risk of metastasis (spread) or recurrence. This information could help veterinarians better understand a dog's tumor and guide treatment decisions.
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Abstract
To evaluate the clinical usefulness of tissue and serum gelatinase activity as a prognostic marker of canine tumors, tissue samples from 60 tumors and corresponding serum samples from the same animals were collected at the time of biopsy and surgery. On the basis of histopathology and clinical aggressiveness of metastasis and recurrence (MR), the cases were divided into 6 categories: non-inflammatory (Inf(-)) and inflammatory (Inf(+)) benign, and the Inf(-) MR(-), Inf(-) MR(+), Inf(+) MR(-), and Inf(+) MR(+) malignant. Gelatinase activity was determined semi-quantitatively using gelatin zymogram with a gelatinase standard from cultured canine peripheral blood mononuclear cells stimulated with lipopolysaccharide. No significant difference in gelatinase activities in tissue extracts was evident between the benign and malignant tumors. Inf(+) benign tumors, as well as Inf(-) MR(+), Inf(+) MR(-) and Inf(+) MR(+) malignant tumors, showed significantly higher tissue gelatinase activity than Inf(-) benign. The tissue activity in Inf(-) MR(-) malignant was significantly lower than in Inf(+) MR(-) and Inf(+) MR(+) malignant. The serum activity was significantly higher in the malignant cases than in the control and the benign. Inf(-) MR(+), Inf(+) MR(-) and Inf(+) MR(+) malignant tumors induced significantly higher gelatinase activity in serum than Inf(-) benign tumors. Gelatinase activity in serum was positively correlated with that in tumor extracts. Increased gelatinase in tumor tissue and serum may be correlated with inflammation as well as tumor aggressiveness, and thus should be used in combination with histopathology for predicting tumor metastasis or recurrence.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16141663/