Peer-reviewed veterinary case report
Dilated intestinal crypts linked to protein loss in dogs
By Willard, M D et al.Ā·Published in Journal of veterinary internal medicineĀ·2000Ā·Department of Small Animal Medicine and Surgery, United StatesĀ·View original on PubMed ā
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research ā every detail traces back to the citation above. How we work ā
Original publication title: Intestinal crypt lesions associated with protein-losing enteropathy in the dog.
- Species:
- dog
Plain-English summary
Six dogs were diagnosed with protein-losing enteropathy (PLE), a condition where the intestines lose protein, leading to symptoms like weight loss and diarrhea. In most cases, the dogs showed dilated intestinal crypts, which are tiny glands in the intestine, filled with mucus and inflammatory cells. While some dogs had additional signs of inflammation, the exact cause of PLE in these cases remains unclear. However, the presence of these dilated crypts seems to be linked to the condition. Treatment options would typically focus on managing the symptoms and underlying causes, but specific outcomes weren't detailed in the study.
People also search for: dog protein losing enteropathy symptoms Ā· dog diarrhea and weight loss Ā· treatment for dog intestinal issues
Abstract
Six dogs were diagnosed with protein losing enteropathy (PLE). There was no evidence of inappropriate inflammatory infiltrates or lymphangiectasia in multiple mucosal biopsies of the small intestine of 4 of the dogs. The 5th and 6th dogs had obvious lymphangiectasia and a moderate infiltrate of inflammatory cells in the intestinal mucosa. All 6 dogs had a large number of dilated intestinal crypts that were filled with mucus, sloughed epithelial cells, and/or inflammatory cells. Whether PLE occurs in these dogs because of protein lost from the dilated crypts into the intestinal lumen or whether the dilated crypts are a mucosal reaction due to another undetermined lesion that is responsible for alimentary tract protein loss is unknown. However, when large numbers of dilated intestinal crypts are present, they appear to be associated with PLE even if there are no other remarkable lesions in the intestinal mucosa.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10830544/