Peer-reviewed veterinary case report
Intestinal injury and vasculitis markers in cats with feline
By Gülersoy, Erdem et al.·Published in Veterinary medicine and science·2023·Department of Internal Medicine·View original on PubMed →
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Original publication title: Intestinal injury and vasculitis biomarkers in cats with feline enteric coronavirus and effusive feline infectious peritonitis.
- Species:
- cat
Plain-English summary
A group of cats with fluid buildup in their abdomen or chest due to feline infectious peritonitis (FIP) showed higher levels of certain markers indicating intestinal injury compared to cats with a less severe feline enteric coronavirus (FECV) infection. The study found that cats with thoracic effusion had different levels of these markers, suggesting they might have a more serious condition. These findings could help veterinarians understand the severity of the disease and guide treatment decisions. Monitoring these biomarkers may improve outcomes for affected cats.
People also search for: cat FIP symptoms · feline coronavirus treatment · cat abdominal effusion signs
Abstract
OBJECTIVE: To investigate intestinal injury, repair and vasculitis biomarkers that may illuminate the progression and/or pathogenesis of feline infectious peritonitis (FIP) or feline enteric coronavirus (FECV) infection. MATERIALS AND METHODS: A total of 40 cats with effusive FIP (30 with abdominal effusion, AE group; 10 with thoracic effusion, TE group) and 10 asymptomatic but FECV positive cats (FECV group), all were confirmed by reverse transcription polymerase chain reaction either in faeces or effusion samples. Physical examinations and effusion tests were performed. Trefoil factor-3 (TFF-3), intestinal alkaline phosphatase (IAP), intestinal fatty acid binding protein (I-FABP), myeloperoxidase-anti-neutrophilic cytoplasmic antibody (MPO-ANCA) and proteinase 3-ANCA (PR3-ANCA) concentrations were measured both in serum and effusion samples. RESULTS: Rectal temperature and respiratory rate were highest in the TE group (p < 0.000). Effusion white blood cell count was higher in the AE group than TE group (p < 0.042). Serum TFF-3, IAP and I-FABP concentrations were higher in cats with effusive FIP than the cats with FECV (p < 0.05). Compared with the AE group, TE group had lower effusion MPO-ANCA (p < 0.036), higher IAP (p < 0.050) and higher TFF-3 (p < 0.016) concentrations. CLINICAL SIGNIFICANCE: Markers of intestinal and epithelial surface injury were higher in cats with effusive FIP than those with FECV. Compared to cats with abdominal effusions, markers of apoptosis inhibition and immunostimulation to the injured epithelium were more potent in cats with thoracic effusion, suggesting the possibility of a poorer prognosis or more advanced disease in these patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37872840/