Peer-reviewed veterinary case report
Intracerebral Astrocytoma in a Horse.
- Journal:
- Journal of comparative pathology
- Year:
- 2020
- Authors:
- Cavasin, J P et al.
- Affiliation:
- Department of Biomedical Sciences · United States
- Species:
- horse
Plain-English summary
An 8-year-old Anglo-European gelding was showing signs of worsening neurological problems and was humanely put to sleep. During the examination after death, a 1.5 cm mass was found in the right side of the brain, which was identified as an astrocytoma, a type of brain tumor. The tumor showed specific markers that confirmed its type, and there were many reactive cells around it, indicating inflammation. Although brain tumors are uncommon in horses, they should be considered when a horse has ongoing neurological issues. Unfortunately, the treatment options were not applicable since the horse was euthanized.
Abstract
An 8-year-old Anglo-European gelding with progressive neurological signs was humanely destroyed and submitted for necropsy examination. The right parietal cortex was disrupted by a well-demarcated, intraparenchymal, 1.5 cm diameter, tan, homogeneous, dense mass. Microscopical examination was consistent with an astrocytoma, which was confirmed on the basis of strong immunohistochemical labelling for glial fibrillary acidic protein. The neoplastic population lacked immunolabelling for oligodendrocyte transcription factor 2. Labelling for ionized calcium binding adaptor molecule 1 highlighted large numbers of reactive microglia throughout the proliferation and in the adjacent neuroparenchyma. While rare, primary brain tumours should be considered as a differential in horses presenting with progressive neurological signs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32505235/