Peer-reviewed veterinary case report
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats.
- Journal:
- Alcohol and alcoholism (Oxford, Oxfordshire)
- Year:
- 2017
- Authors:
- Israel, Yedy et al.
- Affiliation:
- Institute of Biomedical Sciences
- Species:
- rodent
Abstract
Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats consumed alcohol for 3 months and were subjected to repeated alcohol deprivations for 7-14 days, followed by alcohol reaccess. Upon reaccess, animals consumed 2.2 g alcohol/kg in 60 minutes. A single intra-cerebroventricular MSC administration inhibited relapse-like drinking up to 80-85% for 40 days (P < 0.001). An alcohol-use-disorder was prevented.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27651282/