Peer-reviewed veterinary case report
Intracerebroventricular infusion of D-serine decreases nociceptive behaviors induced by electrical stimulation of the dura mater of rat.
- Journal:
- Neurological research
- Year:
- 2019
- Authors:
- Wang, Xiaolin et al.
- Affiliation:
- a Department of neurology · China
- Species:
- rodent
Abstract
OBJECTIVE AND METHOD: D-serine acts as an obligatory ligand for the glycine sites of N-methyl-D-aspartate receptors. To investigate its effect on head-facial pain, nociceptive behaviors of rats induced by electrical stimulation of the dura mater were observed after cerebroventricular infusion of D-serine. RESULTS: Rats in the D-serine infusion group showed significantly fewer nociceptive behaviors, including grooming and head flicking, than rats in the saline infusion group and control rats. CONCLUSIONS: This is the first study to introduce D-serine to a trigeminovascular headache model that demonstrates an antinociceptive-like effect in rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30585136/