Peer-reviewed veterinary case report
Intracoronary injection of granulocyte colony-stimulating factor ameliorates the progression of left ventricular remodeling after myocardial ischemia/reperfusion in rabbits.
- Journal:
- Circulation journal : official journal of the Japanese Circulation Society
- Year:
- 2006
- Authors:
- Hasegawa, Hiroshi et al.
- Affiliation:
- Department of Cardiovascular Science and Medicine · Japan
- Species:
- rabbit
Abstract
BACKGROUND: Although granulocyte colony-stimulating factor (G-CSF) is known to prevent left ventricular (LV) remodeling after acute myocardial infarction (AMI), the best method of administration is unknown. METHODS AND RESULTS: A rabbit ischemia/reperfusion model was created and G-CSF was administered into the coronary artery immediately after reperfusion. The LV size and contraction were determined by echocardiography, and the extent of infarcted myocardium was measured by Masson-Trichrome staining. The benefits of intracoronary injection of G-CSF on LV remodeling were similar to subcutaneous injection. CONCLUSIONS: Direct intracoronary G-CSF injection may become a new therapy for AMI with lower adverse effects.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16799254/