Peer-reviewed veterinary case report
Dog with brain tumor causing neurological signs for 3 months
By Liu, Chen-Hsuan et al.·Published in The Journal of veterinary medical science·2004·Department of Veterinary Medicine·View original on PubMed →
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Original publication title: Intracranial granular cell tumor in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old female miniature poodle had been showing neurological signs for three months, which raised concerns for her owner. An MRI revealed a tumor in the right side of her brain that was pressing on nearby structures. Unfortunately, after she passed away, a necropsy confirmed the presence of a granular cell tumor, a type of brain tumor. This condition can lead to serious symptoms, and treatment options may vary, but in this case, the outcome was not favorable.
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Abstract
A 12-year-old female miniature poodle showed a 3-month history of neurological signs. Magnetic resonance imaging disclosed a high intensity tumor mass in the right cerebral hemisphere with compression of the lateral ventricle. At necropsy, a 2 x 3 cm white, friable mass was found in the right ventral pyriform lobe. Microscopically, the tumor cells were large, polygonal to round cells supported by a sparse fibrovascular stroma. The tumor cells typically possessed finely granular, pale eosinophilic cytoplasm with strongly positive periodic acid-Schiff (PAS) reaction. The tumor cells were immunopositive for vimentin, NSE and S-100. Ultrastructurally, the tumor cells showed large amounts of granules in the cytoplasm, and absence of basement membrane. Based on the above-mentioned findings, the intracranial granular cell tumor was diagnosed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/14960817/