Peer-reviewed veterinary case report
Injection of heat-killed Mycobacterium vaccae for dog atopic
By Ricklin Gutzwiller, Meret E et al.·Published in Veterinary dermatology·2007·Department of Clinical Veterinary Medicine·View original on PubMed →
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Original publication title: Intradermal injection of heat-killed Mycobacterium vaccae in dogs with atopic dermatitis: a multicentre pilot study.
- Species:
- dog
Plain-English summary
A group of 62 dogs with atopic dermatitis (a skin allergy causing itching and inflammation) received a single injection of heat-killed Mycobacterium vaccae to see if it would help reduce their symptoms. The treatment was well tolerated and showed positive results in mild to moderate cases, with improvements lasting for about three months. However, it did not have a significant effect on dogs with more severe symptoms. This could be a potential option for pet owners looking for new treatments for their dog's skin allergies.
People also search for: dog itching treatment · atopic dermatitis in dogs · Mycobacterium vaccae for dogs
Abstract
Canine atopic dermatitis (cAD) is a common disease with a multifactorial aetiology associated with impaired immunoregulation. The immunopathogenesis has similarities to that of human atopic dermatitis. Clinical signs of allergic disease in humans and mice are reduced by administration of saprophytic mycobacteria that amplify regulatory cytokines and hence the effect of Mycobacterium vaccae on the clinical severity of cAD was investigated. Sixty-two dogs with cAD, selected according to strict criteria, were treated with a single intradermal injection and evaluated monthly for 3 months in a placebo-controlled double-blind clinical trial. Clinical severity was quantified using standardized scores and by owner assessment of pruritus. A single injection of a heat-killed suspension of M. vaccae was found to be well tolerated and effective in treating mild to moderate cases of cAD demonstrable for 3 months, but was insignificant in more severely affected dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17355422/