Peer-reviewed veterinary case report
Dogs with atopic dermatitis have weaker skin reactions to histamine
By Marsella, R & Nicklin, C F·Published in Veterinary dermatology·2001·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Intradermal skin test reactivity to histamine and substance P is blunted in dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy condition) showed reduced skin reactions to certain allergy tests compared to healthy dogs. When injected with substance P, a substance that can cause itching and inflammation, these dogs had smaller reactions than the normal dogs did. This suggests that their skin may not respond as strongly to allergens. Understanding this could help veterinarians develop better treatments for dogs suffering from skin allergies.
People also search for: dog skin allergy treatment · why is my dog itching · atopic dermatitis in dogs · substance P and dog allergies
Abstract
Skin reactivity to intradermal injections (0.1, 0.5 and 1 nM) of substance P (SP) was evaluated in 20 clinically normal dogs and 20 dogs with atopic dermatitis (AD). Saline and histamine were used as negative and positive controls, respectively. Wheal diameters were measured. Reactions were evaluated for erythema and induration and a subjective score, on a scale from 0 to 4+, was given. Evaluations were performed at 3, 5, 10, 15 and 30 min after the injections. Wheal diameters for histamine and SP injections were significantly smaller in dogs with AD compared with clinically normal dogs. In both groups, reactions to the various concentrations of SP were not significantly different from each other and were always smaller than histamine reactions. Erythema was not seen with SP injections. In addition, subjective scores for SP injections were significantly lower in dogs with AD compared with controls. The results of this study are similar to those reported in human medicine, where a role for SP in AD is proposed and desensitization of receptors to both SP and histamine is hypothesized. Further studies are needed to investigate the role of SP in the pathogenesis of canine AD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11420930/