Peer-reviewed veterinary case report
Dog with progressive hind-limb stiffness diagnosed with spinal
By Cantile, C et al.·Published in Veterinary pathology·2003·Dipartimento di Patologia Animale, Italy·View original on PubMed →
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Original publication title: Intramedullary hemangioblastoma in a dog.
- Species:
- dog
Plain-English summary
A 6-year-old male Pointer was brought to the vet with a 4-week history of stiffness in his back legs. An MRI revealed a tumor in the spinal cord, which was confirmed during a necropsy. The tumor was identified as a hemangioblastoma, a type of tumor made up of blood vessels and supporting cells. Unfortunately, the dog did not survive, but this case highlights the importance of recognizing similar tumors in dogs as they can occur in humans as well.
People also search for: dog hind limb stiffness · Pointer dog spinal tumor · hemangioblastoma in dogs
Abstract
A 6-year-old male Pointer dog was presented with a 4-week history of progressive hind-limb stiffness. Magnetic resonance imaging demonstrated a focal intramedullary lesion at T1 level with a pattern of ring contrast enhancement. At necropsy, a circumscribed intramedullary reddish-gray tumor was observed. Microscopically, the tumor was composed of thin-walled capillaries lined by endothelial cells and separated by pleomorphic cells (stromal cells) with a moderate degree of anisokaryosis. Immunohistochemically, the endothelial cells were positive for factor VIII-related antigen and the stromal cells were positive for neuron-specific enolase and vimentin. GFAP-positive astrocytes were occasionally observed within the tumor. Both endothelial and stromal cells were negative for synaptophysin, S-100 protein, pankeratin, smooth muscle actin, CD34, CD68, alpha1-antichymotrypsin, and lysozyme. The tumor showed considerable morphologic and immunohistochemical similarities with human hemangioblastoma, and hence the inclusion of this tumor type within the primary neoplasms of the canine central nervous system is suggested.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12627718/