Peer-reviewed veterinary case report
Intranasal immunization with an adenovirus vaccine protects guinea pigs from Ebola virus transmission by infected animals.
- Journal:
- Antiviral research
- Year:
- 2015
- Authors:
- Wong, Gary et al.
- Affiliation:
- Department of Medical Microbiology · Canada
- Species:
- rodent
Abstract
Experimental Ebola virus (EBOV) vaccines have previously been shown to protect animals against a high dose intramuscular (IM) challenge, which is seen as a stringent challenge model. However, the protective efficacy against other modes of infection, such as contact with infectious hosts, is unknown. Using a previously established EBOV transmission animal model, we evaluated the efficacy of an adenovirus-based EBOV vaccine given to guinea pigs (gps) 4weeks before direct contact with untreated, infectious animals. Prior vaccination resulted in robust levels of EBOV-specific antibodies and conferred complete protection in gps. These results support the use of vaccines to prevent EBOV transmission between hosts.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25596432/