Peer-reviewed veterinary case report
Using indocyanine green dye to find liver cancer during dog surgery
By Iida, G et al.·Published in The Journal of small animal practice·2013·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Intraoperative identification of canine hepatocellular carcinoma with indocyanine green fluorescent imaging.
- Species:
- dog
Plain-English summary
A group of six dogs with liver nodules underwent surgery to remove these growths, which were suspected to be cancerous. Before the operation, the dogs were given a special dye called indocyanine green, which helps highlight tumors during surgery. The results showed that out of twelve nodules, six were confirmed as liver cancer (hepatocellular carcinoma), and the imaging technique successfully identified some of these tumors. All dogs had their nodules completely removed, suggesting that this imaging method could help veterinarians better locate and treat liver cancer in dogs.
People also search for: dog liver cancer treatment · indocyanine green for dog tumors · how to identify liver tumors in dogs
Abstract
OBJECTIVES: To evaluate the feasibility of high-sensitivity near-infrared fluorescence imaging with indocyanine green for intraoperative identification of hepatocellular carcinoma in dogs. METHODS: Twelve hepatic nodules were surgically resected from six dogs. In each dog, 0 · 5 mg/kg indocyanine green was intravenously injected for 12 to 18 hours preoperatively. The hepatic nodules were investigated under laparotomy using a near-infrared fluorescence imaging light camera system prior to resection. Resected nodules were histopathologically diagnosed and their fluorescence images were evaluated. RESULTS: Of the 12 hepatic nodules, 6 were diagnosed as hepatocellular carcinoma and 6 as nodular hyperplasia. Indocyanine green-fluorescence was observed in four large hepatocellular carcinoma nodules and one case of nodular hyperplasia, whereas it was absent in the remaining nodules. The sensitivity and positive predictive values of indocyanine green fluorescent imaging for hepatocellular carcinoma was 71 · 4 and 80 · 0%, respectively. Complete resection of the hepatic masses was achieved in all dogs. CLINICAL SIGNIFICANCE: Near-infrared fluorescence imaging may be feasible for intraoperative mapping of hepatocellular carcinomas in hepatic lobes and may help increase the chance of complete resection of hepatocellular carcinoma in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24580016/