Peer-reviewed veterinary case report
Persimmon tannin gel helps reduce dog gum disease and bad breath
By Toyooka, Megu et al.·Published in Journal of pharmacological sciences·2025·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Intraoral treatment of persimmon tannin, a polyphenol extracted from persimmon, significantly ameliorates gingivitis, plaque and halitosis via directly influence the periodontal bacteria Porphyromonasgulae.
- Species:
- dog
Plain-English summary
A group of dogs with gum disease were treated with a gel containing persimmon tannin, a natural compound from persimmons, to see if it could help reduce bad breath and plaque. While the treatment didn't significantly change the overall gum health or plaque levels, it did lower the levels of certain harmful gases produced by bacteria in the mouth. This suggests that persimmon tannin could be beneficial in managing periodontal disease in dogs.
People also search for: dog gum disease treatment · bad breath in dogs · persimmon tannin for dogs
Abstract
BACKGROUND: As periodontal disease (PD) is an irreversible disorder, preventive dentistry in human and veterinary medicine has become pertinent. This study focused on persimmon tannin (PT) and examined its bactericidal, anti-halitosis, and anti-inflammatory effects by focusing on Porphyromonas gulae (P. gulae). METHODS: The direct effects of PT on P. gulae were evaluated in vitro. Pro-inflammatory cytokines secretion induced by P. gulae in the macrophage cell lines were determined. A clinical study in dogs with P. gulae-associated PD was performed by one-month intraoral treatment with 0.1% PT-containing gel. RESULTS: PT exhibited a significant bactericidal effect to P. gulae. The biofilm formation and methyl mercaptan generated by P. gulae was significantly decreased by PT even after a short exposure period. P. gulae-induced proinflammatory cytokine production in macrophage cell lines was inhibited by PT treatment in a dose-dependent manner. In a clinical study of dogs, intraoral treatment with 0.1% PT did not significantly influence the gingivitis and plaque scores, however, the concentrations of hydrogen sulfide and methyl mercaptan were also significantly decreased by the PT treatment. Although there was no anti-bacterial in vitro, P. gulae activity and DNA detection decreased with PT treatment. CONCLUSIONS: These findings suggest that intraoral administration of PT can prevent PD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40058939/